Sisters Mainstreet Cafe

312 Grand Ave, Spencer, IA 51301, United States
+1 712-580-6803
$$$ Cafe
(69 Reviews)
Price Range $10–20

If you're looking for a cozy spot to indulge in a hearty breakfast or enjoy a delightful brunch, look no further than Sisters Mainstreet Cafe. Nestled at 312 Grand Ave in Spencer, Iowa, this charming cafe is truly a hidden gem that captures the essence of small-town hospitality. With a menu filled with delicious options and a warm, inviting atmosphere, it's no wonder that locals and visitors alike return time and again.

The cafe specializes in classic American breakfast fare that will have your taste buds dancing with delight. The House Special, a favorite among regulars, showcases a delightful combination of flavor that starts your day off right. If you're a fan of omelets, you can’t miss the Western Omelet or the All Meat Omelet, both generously stuffed with fresh ingredients that are cooked to perfection. Each dish is crafted with care, and you'll find that the portions are not just generous, but downright filling, like the Chicken Fried Steak and the glorious fluffy pancakes that are almost too big for the plate!

One customer, Terry Morfitt, raves, “Hands down best breakfast in the city, county, and state,” going on to describe the “beautiful ribbons of delicious bacon” and “sticky rolls” that are oh-so-hard to resist. There’s something about the fresh-baked bread that feels like a warm hug from the moment you take that first bite. And don’t be surprised if you find yourself chatting away with the friendly patrons – as Nolan discovered, sometimes what starts as a quick stop can turn into a cherished hour of laughter and conversation.

The atmosphere at Sisters Mainstreet Cafe is casual and welcoming, where “seat yourself” is just the beginning of your journey. The personal touch from the staff makes every visit feel like coming home; many customers, including Pedro Godinez, appreciate how “welcoming and homy” the space feels, making it the perfect place to kickstart your day with a smile. The decor reflects a quaint charm that draws you in, while the delicious aromas wafting from the kitchen beckon you to indulge.

Sisters Mainstreet Cafe operates on a cash or check basis, a unique touch that might remind you of simpler times. So, please ensure you're prepared for your visit! The community spirit here is palpable and is just one element that contributes to its reputation as a must-visit spot in Spencer.

If you find yourself in the area, you owe it to yourself to experience the warmth and flavor of Sisters Mainstreet Cafe. Whether you're a local or a traveler passing through, this cafe promises not just a meal, but a delightful experience that lingers long after the last bite.

Service options
Takeaway
Dine-in
Delivery
Highlights
Great coffee
Popular for
Breakfast
Lunch
Solo dining
Good for working on laptop
Accessibility
Wheelchair-accessible car park
Wheelchair-accessible entrance
Wheelchair-accessible seating
Wheelchair-accessible toilet
Offerings
Coffee
Comfort food
Healthy options
Quick bite
Small plates
Dining options
Breakfast
Brunch
Lunch
Dessert
Seating
Table service
Amenities
Toilet
Atmosphere
Casual
Cosy
Historic
Crowd
Groups
Tourists
Children
Good for kids
High chairs
Parking
Free of charge street parking
Free parking lot
Openings Hours
Checking

Monday

05:00 AM - 11:00 AM

Tuesday

05:00 AM - 11:00 AM

Wednesday

05:00 AM - 11:00 AM

Thursday

05:00 AM - 11:00 AM

Friday

05:00 AM - 11:00 AM

Saturday

05:00 AM - 11:00 AM

Sunday

Closed

69 Reviews
Nolan

18 Aug 2025

I was going to go in and get out in like 20 minutes but I walk in and I see so many older folk and I started talking I not 20 minutes but 1 hour and 30 minutes of talking and it was so of my favourite time I have had talking.

Jessie Sorensen

17 Aug 2025

Very delicious and reasonable prices very friendly staff highly recommend

Mike Christy

11 Aug 2025

Came here on vaccination with my girlfriend. Wonderful food and even more wonderful service. This is what small town Iowa is all about. Come check em out for breakfast you won’t regret it

Karla Ahl

04 Aug 2025

Was awkward walking in first time not knowing it was seat yourself and everyone staring at the out of towners. However, it became better as the food was very good and delivered quickly and hot. Toast was definitely on point and some of the best I have had. Prices are reasonable. Is cash or check only so be prepared for that.

Terry Morfitt

29 Jul 2025

I love Sister's Cafe. Hands down best breakfast in the city, county, and state. The pancakes were bigger then a diner plates. Bacon are in beautiful ribbons of delicious of pork. My eggs and yours, done to your perfect request. I can't believe I haven't mention the fresh baked bread and the sticky rolls, OMG !! If you're not from Spencer get here to try Sister's Cafe. If you are from Spencer you don't know what you are missing if you haven't ate at Sister's.

seaglass sparkles

21 Jun 2025

This is a hidden gem in Spencer, Iowa. My siblings and I found it this summer during sidewalk days. We came back today but missed the breakfast hours!!! We were so disappointed. We need to get to Spencer earlier. It’s a wonderful restaurant with friendly employees and patrons who greet us as we walk in. Love this place!

Pedro Godinez

03 Jun 2025

It's a very nice place, very welcoming and homy, it's nice to see how welcomed you feel once you sit. These ladies are ver active.

Cameron Sieradzan

27 May 2025

Food was delicious and filling. I had the veggie omelet. There was more food on my plate than I could eat!

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